Certified Advanced Alcohol and Drug Counselor (CAADC) Practice Exam

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What is the typical elimination half-life range for buspirone?

5-30 hours
30-100 hours
2-8 hours
20-50 hours

The correct answer is: 2-8 hours

Buspirone is an anxiolytic medication primarily used to treat generalized anxiety disorder. The typical elimination half-life of buspirone falls within the range of 2 to 8 hours. This means that after this duration, half of the drug's active substance has been metabolized and eliminated from the body, which is within the expected pharmacokinetic profile for this medication. This relatively short half-life indicates that buspirone does not remain in the body for extended periods, making it less likely to cause prolonged effects or accumulation. As a result, it can be prescribed multiple times a day to maintain its therapeutic effect while minimizing side effects. Other choices represent half-lives that are not consistent with the pharmacokinetics of buspirone. Medication management often considers the half-life when determining dosing schedules to ensure the drug maintains effective levels in the bloodstream, which is not the case with the ranges provided in incorrect options. Hence, the 2 to 8 hour elimination half-life accurately reflects the known data regarding buspirone's clearance from the body.