Certified Advanced Alcohol and Drug Counselor (CAADC) Practice Exam

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What effect does buspirone primarily have in the central nervous system?

Stimulation of adrenaline production

Blocking dopamine receptors

Acting on the dopaminergic system or serotonin receptors

Buspirone primarily acts on the central nervous system by engaging with both dopamine receptors and serotonin receptors. Its primary mechanism involves being a partial agonist at the serotonin 5-HT1A receptors, which is crucial for its anxiolytic (anti-anxiety) effects. Additionally, buspirone also has an impact on the dopaminergic system, albeit to a lesser extent than its influence on serotonin.

This dual action sets buspirone apart from other anxiolytics, such as benzodiazepines, which primarily enhance GABA activity in the brain. By influencing both serotonin and dopamine, buspirone helps in addressing anxiety symptoms without the sedative effects commonly associated with GABAergic medications. This makes buspirone a unique choice for treating anxiety, particularly in patients who may be sensitive to the side effects of other types of medications.

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Enhancing GABA activity

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